Gustavo Murer

Staff Researcher (Independent), Argentine National Research Council

 A common experimental approach in Neuroscience is to study the effects of environmental manipulations on brain activity and behavior, without taking into consideration spontaneous neuronal activity or assuming that it is noise. However the activity of the “resting” brain is highly organized, even during sleep and under anesthesia, and there is evidence that it supports a variety of functions, like the coordination of information flow through the generation of synchronous oscillations, memory consolidation, synaptic homeostasis, and the refinement of connections during development. My main interest is to characterize the mechanisms that coordinate the internal activity states of the frontal cortex and basal ganglia, by using electrophysiology in rodents as experimental approach. More specifically, we are studying the organization of spontaneous cortico-striatal activity in the adult brain, the maturation of the internal activity states in these circuits during infancy and adolescence, and the functional connectivity of frontal cortex – basal ganglia networks in conditions of reduced dopamine availability that capture some behavioral features of neuropsychiatric conditions like attention deficit hyperactivity disorder and Parkinson’s disease.

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